Efficient RNA delivery by integrin-targeted glutathione responsive polyethyleneimine capped gold nanorods
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چکیده
منابع مشابه
Efficient RNA delivery by integrin-targeted glutathione responsive polyethyleneimine capped gold nanorods.
RNA interference (RNAi) mediated gene silencing holds significant promises in gene therapy. A major obstacle to efficient RNAi is the systemic delivery of the therapeutic RNAs into the cytoplasmon without being trapped in intracellular endo-/lyso-somes. Herein we report the development of a PEGylated, RGD peptide modified, and disulfide cross-linked short polyethylenimines (DSPEIs) functionaliz...
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BACKGROUND Several nanoconjugates have been designed to deliver nucleic acids such as small interfering RNA (siRNA) and DNA to cells to study silencing and expression efficacies. In the present study, we prepared novel epithelial cell adhesion molecule (EpCAM) monoclonal antibody conjugated polyethyleneimine (PEI) capped gold nanoparticles (AuNPs) loaded with EpCAM-specific siRNA molecules to k...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2015
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2015.05.028